The CDC advises extreme caution when traveling for the holidays. These insights from experts in medicine, infectious disease, and air quality can help to limit the risks.

James McDeavitt, MD, has a plan to see his family this Thanksgiving.He’ll be traveling from Houston, Texas, where he is the senior vice president and dean of clinical affairs at Baylor College of Medicine, to coastal South Carolina, where he’ll meet up with extended family members ranging in age from five months to 78 years old.

The potential for spreading the virus that causes COVID-19 under such circumstances is worryingly high, McDeavitt says. Many of the things that would happen during a normal family Thanksgiving gathering — traveling from out of state; spending time inside talking, eating, and singing; hugging elderly relatives — are a recipe for a superspreading event.