Methylfolate is the active and natural form of folate, also known as vitamin B9. Methylfolate is the only form of folate that can cross the blood-brain barrier to help facilitate the synthesis of the neurotransmitters: serotonin, dopamine and norepinephrine. These neurotransmitters are associated with mood regulation.
When we take folic acid supplement or eat folic acid fortified foods, we rely on Methylenetetrahydrofolate reductase (MTHFR), a gene and enzyme found throughout the body that converts folic acid to its active form, L-methylfolate.
For those who have a gene mutation affecting the MTHFR enzyme, their bodies are unable to convert folic acid to methylfolate. For this reason, it’s important for them to take methylfolate rather than just folic acid in order for their bodies to utilize the vitamin. If someone with a gene mutation or digestive condition takes folic acid, this can result in unmetabolized folic acid which has been linked to poor immune function and a variety of other health conditions.
Comes in a 1 oz high potency bioavailable spray.